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直肠癌根治术后复发者约有半数病人死于局部复发。为此,作者设计了一种盆腔加温装置,对晚期直肠癌病人施行术中盆腔高温化疗(IOPHC),通过高温对癌细胞的选择性杀伤作用和促进化疗药物的抗肿瘤作用,达到清除残余癌细胞,防止直肠癌局部复发的目地。作者自1988年10月开始研究直肠癌高温疗法,灌注盆腔的生理盐水温度为45～47℃。切除直肠和广泛淋巴结清扫术后即用预先加温并含40μg/ml丝裂霉素C(MMC)的生理盐水充满盆腔
About half of patients who have recurrence of rectal cancer have died of local recurrence. To this end, the authors designed a pelvic warming device for the implementation of intraoperative pelvic hyperthermic chemotherapy (IOPHC) in patients with advanced rectal cancer, through the selective killing of cancer cells by high temperature and promote the anti-tumor effect of chemotherapeutic drugs, to achieve the removal of residual Cancer cells prevent the local recurrence of rectal cancer. The authors began to study rectal cancer hyperthermia therapy in October 1988. The temperature of saline in the pelvic cavity was 45 to 47°C. After excision of the rectum and extensive lymph node dissection, the pre-warmed saline solution containing 40 μg/ml mitomycin C (MMC) was used to fill the pelvic cavity.