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目的 :研究酶酚酸酯 (MMF)对大鼠肾病综合征的治疗作用 ,为临床应用提供依据。方法 :经尾静脉一次性注射阿霉素 ,构建大鼠肾病综合征动物模型 ,观察MMF对大鼠肾病综合征血、尿生化指标、淋巴细胞电压依赖性钾通道及肾脏组织学改变的影响 ,并与强的松进行对照研究。结果 :注射阿霉素 14d ,大鼠肾病综合征模型建立 ,模型鼠表现外周T淋巴细胞电压依赖性钾通道电流增强。MMF治疗可使大鼠尿蛋白和血尿素氮明显下降 ,血白蛋白上升 ,肾脏病理显示足突无明显融合 ,疗效明显优于强的松治疗组。结论 :在阿霉素诱导的大鼠肾病综合征模型的形成中 ,细胞免疫参与了其发病。MMF能明显改善模型鼠的肾功能并减轻肾脏组织形态学损害 ,且疗效优于强的松
Objective: To study the therapeutic effect of enzyme-linked phenate (MMF) on nephrotic syndrome in rats and provide the basis for its clinical application. Methods: A rat model of nephrotic syndrome was established by injection of doxorubicin through the tail vein. The effects of MMF on the blood and urine biochemical parameters, the voltage-dependent potassium channel of lymphocytes and the renal histological changes were observed. And compared with prednisone control. Results: After adriamycin injection for 14 days, the rat model of nephrotic syndrome was established. The model mice showed enhanced voltage-dependent potassium currents in peripheral T lymphocytes. MMF treatment can significantly reduce urinary protein and blood urea nitrogen, serum albumin increased, renal pathology showed no significant integration of the foot process, the effect was significantly better than prednisone treatment group. CONCLUSIONS: Cellular immunity is involved in the pathogenesis of doxorubicin-induced nephrotic syndrome in rats. MMF can significantly improve the renal function of model mice and reduce renal histological damage, and the effect is superior to prednisone