论文部分内容阅读
目的探讨根除幽门螺杆菌(Hp)对Hp阳性的功能性消化不良(FD)患者症状的治疗作用。方法189例经胃镜检查Hp阳性的FD随机分为两组:治疗组给予奥美拉唑20 mg,阿莫西林1 g,克拉霉素500 mg,均2次/d,治疗1周;对照组给予奥美拉唑20 mg,每天2次和多潘立酮10 mg,3次/d,治疗1周。治疗后一个月行14C-尿素呼气试验,并进行症状评分及疗效评定;随访1年再进行14C-尿素呼气试验,并进行症状评分。结果治疗组Hp根除率81.9%,其中Hp根除组1个月后和1年后的症状改善显效率分别为38.9%、32.5%与对照组的12.6%、7.3%及Hp根除失败组相比差异具有统计学意义(P<0.01)。结论根除Hp可以在较长时间内改善FD症状,可作为治疗Hp阳性功能性消化不良的主要措施。
Objective To investigate the therapeutic effect of eradication of Helicobacter pylori (Hp) on the symptoms of Hp-positive patients with functional dyspepsia (FD). Methods 189 cases of Hp positive FDG were randomly divided into two groups: the treatment group was given omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg twice a day for 1 week; control group Omeprazole 20 mg twice daily and domperidone 10 mg 3 times daily for 1 week. One month after treatment, 14 C-urea breath test was performed and the symptom scores and therapeutic effects were evaluated. One-year follow-up followed by 14 C-urea breath test and symptom score. Results The eradication rate of Hp in the treatment group was 81.9%. The effective rates of symptoms improvement after one month and one year in Hp eradication group were 38.9% and 32.5%, respectively, compared with 12.6% and 7.3% in control group and Hp eradication failure group With statistical significance (P <0.01). Conclusion The eradication of Hp can improve FD symptoms in a long time and can be used as the main measure to treat Hp-positive functional dyspepsia.