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目的了解浙江省湖州市自然人群A群C群流行性脑脊髓膜炎(流脑)抗体水平及相关性,为制定防制策略提供依据。方法采用分层随机抽样方法,分7个年龄组,采集635份健康人群血清,采用酶联免疫吸附试验检测A群、C群流脑Ig G抗体含量,对A群和C群流脑抗体水平进行描述流行病学和相关性分析。结果 A群流脑抗体阳性率和保护率为89.92%和81.89%,C群流脑则为85.20%和63.76%,A群流脑抗体水平总体高于C群。A群流脑各年龄组间阳性率、保护率和抗体含量间存在正相关,7岁以上年龄组C群流脑抗体保护率和含量降幅较阳性率明显,仅保护率和抗体含量间存在正相关。A群、C群流脑抗体各年龄组间同时阳性和同时具有保护水平与C群流脑存在正相关。A群、C群流脑抗体保护率年龄分布均呈单峰分布,其中A群流脑以7~14岁组为最高,C群高峰则在3~4岁组。5岁以下人群A群、C群流脑抗体阳性率、保护率、抗体含量差异无统计学意义,且抗体保护水平定性检测结果存在一致性。结论湖州市存在C群流脑流行的血清学基础,需进一步加强含C群流脑成分疫苗接种。建议使用A群C群流脑结合疫苗代替2岁以内接种的A群流脑多糖疫苗,并对2岁以上儿童直接使用A群C群流脑多糖疫苗进行接种。
Objective To understand the level and correlation of epidemic cerebrospinal meningitis (meningococcal group A) C group A natural population in Huzhou, Zhejiang Province, and to provide basis for the development of control strategy. Methods The stratified random sampling method was used to divide the serum of 635 healthy people in seven age groups. The Ig G antibody levels in group A and group C were detected by enzyme-linked immunosorbent assay (ELISA) Describe the epidemiology and correlation analysis. Results The positive rates and protective rates of meningococcal antibody in Group A were 89.92% and 81.89%, those in Group C meningitis were 85.20% and 63.76% respectively, and those in Group A were higher than those in Group C. There was a positive correlation between positive rate, protective rate and antibody content in each age group of Group A meningitis, and the positive rate of the protective rate and the content of antibody against meningococcal meningitis in group C over 7 years old was significantly positive. There was positive correlation between protection rate and antibody content Related. Group A, Group C meningoencephalitis antibodies of all age groups at the same time positive and at the same time with the level of protection and C group meningitis there is a positive correlation. The age distribution of protection rate of mecca antibody in group A and group C showed a unimodal distribution, in which group A meningitis was the highest in group 7-14 and group C was in group 3 to 4. There was no significant difference in the positive rate, protection rate and antibody content of meningococcal antibody among group A and group C below 5 years old, and there was consistency among the qualitative test results of antibody protective level. Conclusions There is a serological basis for epidemic of Group C meningitis in Huzhou City. It is necessary to further strengthen the vaccination of Group C meningitis components. It is recommended to use group A, group C, meningitis-associated vaccines in place of group A meningitis A vaccines vaccinated within 2 years of age and to vaccinate children older than 2 years directly with group A, group C, meningitis.