抗心律失常治疗中常联合用药,其目的是增加疗效,减少副作用。但不合理的联合应用,可产生不良的相互作用,甚至造成毒性作用的相加。胺碘酮的作用机理比较复杂,口服起效慢,半衰期及药效持续时间较长,与其它抗心律失常药可相互作用,并使之发生动力学,药代学及电生理的变化,联用后可增加疗效,也可出现毒性影响。 Anti-arrhythmia often combined treatment, its purpose is to increase the efficacy and reduce side effects. However, unreasonable joint application can produce undesirable interactions and even add up toxic effects. The mechanism of action of amiodarone is complex, slow onset of oral administration, longer half-life and longer duration of drug action, and other anti-arrhythmic drugs may interact, and make it happen dynamics, pharmacokinetics and electrophysiological changes, the United After use can increase the efficacy, but also toxic effects.