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虽然人类对肿瘤的认识逐渐加深,治疗手段也取得了很大进展,但是恶性肿瘤的治疗效果仍有限。传统治疗初始通常能控制肿瘤生长,取得临床客观缓解,但多数患者最终将经历肿瘤的转移及复发。肿瘤干细胞(cancer stem cells,CSCs)学说认为,肿瘤中的一小部分细胞群体决定着肿瘤的生长及播散,这部分细胞群体称为CSCs。CSCs通过自我更新能力及多向分化潜能确保干细胞池的稳定并生成肿瘤主体细胞维持肿瘤的长期生长。虽然CSCs仅占据肿瘤实体的一小部分,但对传统治疗的高度耐受性使其能够逃避杀伤重新构建肿瘤。因此要想彻底治愈肿瘤,必须清除肿瘤生长、复发及转移的根源——CSCs。本文就靶向作用于CSCs的治疗策略作一综述。
Although human understanding of cancer gradually deepened, and treatment has made great progress, but the treatment effect of malignant tumors is still limited. Traditional treatment of the initial can usually control tumor growth and achieve clinical objective relief, but most patients will eventually undergo tumor metastasis and recurrence. Cancer stem cells (CSCs) doctrine that a small part of the tumor cell population determines the tumor growth and dissemination, this part of the cell population called CSCs. CSCs ensure the stability of the stem cell pool and generate tumor host cells through self-renewal and multidrug differentiation potential to maintain long-term tumor growth. Although CSCs occupy only a small fraction of the tumor mass, their high tolerance to traditional therapies allows them to evade the killing of the tumor. Therefore, in order to completely cure the tumor, it is necessary to remove the tumor growth, recurrence and metastasis of the source - CSCs. This article reviews the therapeutic strategies that target CSCs.