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目的:探讨消痈溃得康的作用机制。方法:健康Wistar大鼠70只,随机分为正常对照组、模型组、消痈溃得康高、低剂量组以及胃康胶囊组、西咪替丁组共6组。结果:消痈溃得康通过对血清NO、NOS含量的影响,从而保护胃黏膜,调节胃黏膜血流量、胃酸分泌。结论:消痈溃得康可以提高胃溃疡愈合质量(QOUH)。
Objective: To explore the mechanism of action of Xiaodan Kudakang. METHODS: Seventy healthy Wistar rats were randomly divided into normal control group, model group, Xiaoyu Kudakanggao, low dose group, Weikang capsule group and cimetidine group. Results: The effect of Xiaoying Kuodakang on the content of NO and NOS in serum could protect the gastric mucosa and regulate the gastric mucosal blood flow and gastric acid secretion. Conclusion: Xiaotan Kudakang can improve the quality of ulcer healing (QOUH).