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目的探讨~(125)I粒子植入联合深部高频热疗治疗复发性宫颈癌的近期临床疗效和安全性。方法将52例盆腔复发性宫颈癌患者分为治疗组和对照组,各26例,治疗组采用~(125)I粒子植入联合高频热疗,对照组采用单纯~(125)I粒子植入,观察两组肿瘤消退情况,此外进行疼痛缓解疗效评估和不良反应评估,组间比较采用卡方检验。结果治疗后2个月,治疗组总有效率(96.2%)高于对照组(73.1%)(χ~2=8.35,P<0.05),疼痛缓解率(88.2%)高于对照组(38.9%)(χ~2=5.33,P<0.05)。治疗后1个月,治疗组急性放射损伤不良反应率和对照组比较,差异无统计学意义(χ~2=2.79,P>0.05)。结论~(125)I粒子植入联合高频热疗治疗复发性宫颈癌近期临床疗效较好,不良反应少。
Objective To investigate the clinical efficacy and safety of ~ (125) I seed implantation and deep hyperthermia in the treatment of recurrent cervical cancer. Methods 52 cases of pelvic recurrent cervical cancer were divided into treatment group and control group, with 26 cases in each group. The treatment group was treated with ~ (125) I seed implantation combined with high frequency hyperthermia, while the control group was treated with 125 I seed implantation Into and observation of tumor regression in both groups, in addition to evaluation of pain relief efficacy and adverse reactions, compared between groups using chi-square test. Results At 2 months after treatment, the total effective rate (96.2%) in the treatment group was significantly higher than that in the control group (73.1%) (χ ~ 2 = 8.35, P < ) (χ ~ 2 = 5.33, P <0.05). One month after treatment, the adverse reaction rate of acute radiation injury in the treatment group was not significantly different from that in the control group (χ ~ 2 = 2.79, P> 0.05). Conclusion ~ (125) I particle implantation combined with high frequency hyperthermia in the treatment of recurrent cervical cancer has good clinical efficacy and few side effects.