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【目的】了解严重急性呼吸综合征 (SARS)是否对患者性腺功能造成了损害。【方法】采用电化学发光免疫技术检测了 2 9例SARS血清雌二醇 (E2 )、黄体生成素 (LH)和睾酮 (T)含量变化 ,并与 5 7例肺结核患者和正常对照组作了比较。【结果】SARS患者血清E2 含量明显低于肺结核组和对照组 ,LH含量明显高于肺结核组和正常对照组 (P <0 .0 5 )。男性SARS患者血清T含量低于肺结核组和正常对照组 ,女性SARS患者血清T含量高于肺结核组和正常对照组。重型SARS患者血清E2 含量显著低于普通型。激素水平恢复要慢于临床症状的改善。发病后 2个月左右激素水平基本恢复正常。肺结核组血清E2 、LH和T含量变化与正常对照组相比无显著性差异 (P >0 .0 5 )。【结论】SARS发病过程中与性功能有关的激素水平发生了变化 ,这些激素水平的恢复可能是一个相对缓慢的过程。
【Objective】 To understand whether severe acute respiratory syndrome (SARS) causes damage to gonadal function in patients. 【Methods】 The contents of estradiol (E2), luteinizing hormone (LH) and testosterone (T) in 29 SARS patients were detected by electrochemiluminescence immunoassay and compared with 57 pulmonary tuberculosis patients and normal control group Compare 【Results】 The serum E2 level in patients with SARS was significantly lower than that in pulmonary tuberculosis and control groups, and the LH content in SARS patients was significantly higher than that in pulmonary tuberculosis and normal controls (P <0.05). The serum T content of male SARS patients was lower than that of pulmonary tuberculosis group and normal control group. The serum T content of female SARS patients was higher than that of pulmonary tuberculosis group and normal control group. Serum E2 levels in patients with severe SARS were significantly lower than those in the common type. Hormone levels recovered more slowly than clinical symptoms improved. About 2 months after onset of hormone levels returned to normal. The levels of E2, LH and T in the tuberculosis group had no significant difference compared with the normal control group (P> 0.05). 【Conclusion】 The changes of sexual function-related hormones in the pathogenesis of SARS have changed. The recovery of these hormones may be a relatively slow process.