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目的观察伊班膦酸钠联合局部放疗治疗骨转移癌患者疼痛的疗效。方法 75例骨转移癌患者随机分为两组,联合治疗组将伊班膦酸钠4mg溶于不含钙离子的0.9%生理盐水500ml,缓慢静脉滴注(不少于4h)同时联合局部放疗;对照组单行放疗。结果联合治疗组的疼痛总缓解率明显高于对照组(P<0.05)。结论伊班膦酸钠联合局部放疗治疗骨转移癌痛疗效确切,可预防病理性骨折的发生,提高了患者的生活质量,毒副反应轻,值得临床进一步观察及应用。
Objective To observe the efficacy of ibandronate combined with local radiotherapy in the treatment of pain in patients with bone metastases. Methods Seventy-five patients with bone metastases were randomly divided into two groups. In the combination therapy group, 4 mg of ibandronate was dissolved in 500 ml of 0.9% saline without calcium ions. The patients in the combination therapy group were treated with slow intravenous drip (no less than 4 hours) combined with local radiotherapy The control group received radiotherapy alone. Results The total pain relief rate in the combined treatment group was significantly higher than that in the control group (P <0.05). Conclusion Ibandronate combined with local radiotherapy for the treatment of bone metastases cancer pain curative effect is exact, can prevent the occurrence of pathological fractures, improve the quality of life of patients, toxic side effects, it is worth further clinical observation and application.