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目的从运动功能、认知功能和自主神经功能障碍方面观察高频重复经颅磁刺激(r TMS)对早期帕金森病(PD)患者的治疗作用。方法将受试者随机分为两组,治疗组用5Hz r TMS治疗31例早期PD患者共10d,30例PD患者作为对照接受假刺激治疗10d。分别于治疗前、疗程结束后和治疗后1个月采用统一PD评定量表第3部分(UPDRS III)、简易智能量表(MMSE)、PD自主神经功能量表(SCOPA-AUT)对两组患者的运动功能、认知功能和自主神经功能进行评定。结果 r TMS治疗10d后及治疗后1个月,31例PD患者UPDRS III,SCOPA-AUT评分显著降低(P<0.05),MMSE评分升高(P<0.05);假刺激组治疗后及治疗后1个月,各指标无统计学差异(P>0.05)。治疗组与假刺激组在治疗后同时间点相比,组间差距有统计学意义(P<0.05)。结论高频r TMS可以短期内改善早期PD患者的运动功能、认知障碍和自主神经功能障碍。
Objective To observe the therapeutic effect of high frequency repetitive transcranial magnetic stimulation (r TMS) on motor function, cognitive function and autonomic dysfunction in patients with early Parkinson’s disease (PD). Methods The subjects were randomly divided into two groups. The treatment group treated 31 cases of early PD with 5 Hz r TMS for 10 days, and 30 cases of PD treated with sham stimulation for 10 days. Before treatment, after the end of treatment and 1 month after treatment, using the Unified PD Rating Scale Part 3 (UPDRS III), simple intelligence scale (MMSE), PD Autonomic Neurological Function Scale (SCOPA-AUT) The patient’s motor function, cognitive function and autonomic function were assessed. Results UPDRS III and SCOPA-AUT scores were significantly lower (P <0.05) and MMSE scores (P <0.05) in the PD patients after 10 days and 1 month after rTMS treatment. After the sham stimulation group and after treatment One month, there was no significant difference between each index (P> 0.05). The difference between the two groups was statistically significant (P <0.05) compared with the sham stimulation group at the same time point after treatment. Conclusion High-frequency r TMS can improve motor function, cognitive impairment and autonomic dysfunction in patients with early PD in a short term.