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目前,表面活性剂在中药制剂中的应用,主要用于药物的增溶、乳化、分散、湿润和有效成分的提取。一、用于难溶性药物的增溶从中草药提取的不少有效成分,如丹参醌ⅡA、大黄素、苦参碱以及挥发性成分如薄荷油、桉叶油、鱼腥草素等在水中的溶解度远远低于治疗所需浓度。使用增溶剂是解决上述问题的有效方法之一。最常用的主要是吐温类,尤其是吐温-80。主要有以下几方面的应用:
At present, the application of surfactants in Chinese medicine preparations is mainly used for the solubilization, emulsification, dispersion, wetting, and extraction of active ingredients of drugs. 1. Solubilization of poorly soluble drugs Many active ingredients extracted from Chinese herbs, such as Salvia miltiorrhiza IIA, emodin, matrine, and volatile components such as peppermint oil, eucalyptus oil, and houttuyfonate are used in water. The solubility is far below the required concentration for treatment. Using a solubilizer is one of the effective ways to solve the above problems. The most common ones are Tweens, especially Tween-80. There are mainly the following applications: