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目的：比较血糖增高的三组不同疾病的糖化血红蛋白（ＨｂＡ１ｃ）含量，探讨ＨｂＡ１ｃ对判断急性脑血管病的临床价值。方法：ＨｂＡ１ｃ测定采用亲和层析法。血糖测定采用葡萄糖氧化酶法。结果：脑血管病引起血糖增高组（１８例），血糖９７４±１６２ｍｍｏｌ／Ｌ，ＨｂＡ１ｃ５０８±１２５％；糖尿病伴脑血管病组（１５例），血糖８４１±１７６ｍｍｏｌ／Ｌ，ＨｂＡ１ｃ８７８±１５７％；单纯糖尿病组（２６例），血糖１００１±３７８ｍｍｏｌ／Ｌ，ＨｂＡ１ｃ９８４±２７３％；正常对照组（２０例），血糖４８５±１３４ｍｍｏｌ／Ｌ，ＨｂＡ１ｃ５４２±０７６％。三组病例的血糖水平与正常对照组相比均有显著差异（Ｐ＜００１）。而ＨｂＡ１ｃ测定，仅脑血管病伴血糖升高组与正常对照比较无差异外，糖尿病组和糖尿病伴脑血管病组均与正常对照组有显著差异（Ｐ＜００１）。结论：ＨｂＡ１ｃ测定除对于糖尿病的诊断有重要参考价值外，还对于脑血管病引起的应激性血糖升高有重要的鉴别价值。
Objective: To compare the levels of HbA1c in three groups of patients with elevated blood glucose, and to explore the clinical value of HbA1c in judging acute cerebrovascular disease. Methods: HbA1c assay using affinity chromatography. Blood glucose determination using glucose oxidase method. Results: Cerebral vascular disease caused by hyperglycemia (18 cases), blood glucose 974 ± 162mmol / L, HbA1c508 ± 125%, diabetes mellitus with cerebrovascular disease (15 cases), blood glucose 841 ± 176mmol / L, HbA1c878 ± 157%; simple diabetic group (26 cases), blood glucose 1001 ± 378mmol / L, HbA1c984 ± 273%; normal control group (20 cases) , Blood glucose 485 ± 134mmol / L, HbA1c5 42 ± 076%. The blood sugar levels of three groups were significantly different from the normal control group (P <001). The HbA1c measurement, only cerebrovascular disease with elevated blood glucose group compared with the normal control no difference, the diabetic group and diabetic patients with cerebral vascular disease group were significantly different from the normal control group (P <0 01). Conclusion: HbA1c assay has important value in the diagnosis of diabetes mellitus, in addition to its important reference value for the diagnosis of diabetes mellitus.