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目的：研究TGF－β与动脉粥样硬化形成的关系。方法：用10％胆固醇脂肪乳剂复制大鼠和家兔的高脂血症模型，免疫组织化学和ELIA等技术检测其动脉和周围血的TGF－β1、β2、β3及其受体，观察比较两种动物动脉粥样硬化形成的情况和血清中的脂蛋白及总胆固醇水平。结果：实验组家兔100％形成动脉粥样斑，血清高密度脂蛋白在正常范围；实验组大鼠未见动脉粥样斑形成，但其血TGF－β和高密度脂蛋白随实验时间（鼠龄）的延长而升高。结论：ITGF－β可能在动脉内膜被高脂血症损伤后的炎性增生反应过程中起作用。
Objective: To study the relationship between TGF-β and atherosclerosis. Methods: Hyperlipidemia rats and rabbits were replicated with 10% cholesterol fat emulsion. The levels of TGF-β1, β2, β3 and their receptors in arteries and peripheral blood were detected by immunohistochemistry and ELIA. Animal atherosclerosis formation and serum lipoprotein and total cholesterol levels. Results: Atherosclerotic plaque was found in 100% of rabbits in experimental group and serum high density lipoprotein was in the normal range. Atherosclerotic plaque formation was not observed in experimental group, but blood TGF-β and high density lipoprotein Age of rats) to extend and increase. Conclusion: ITGF-β may play an important role in the process of inflammatory hyperplasia after intimal hyperplasia is injured by hyperlipidemia.