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目的探讨丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)等生化指标在判断小儿人巨细胞病毒(HCMV)感染中有无肝细胞损伤的参考价值。方法应用荧光定量聚合酶链反应(FQ-PCR)方法检测246例临床疑诊HCMV感染住院患儿血清HCMV-DNA含量,从而将其分为实验组和对照组,并同时检测其ALT、AST、GGT等生化指标。结果巨细胞病毒感染的实验组ALT、AST、GGT均比对照组增高,差异有统计学意义(P<0.05)。结论 ALT、AST、GGT等肝功能相关酶活性升高程度对判断巨细胞病毒感染是否有肝细胞肝脏损害有一定的参考价值,提示在巨细胞病毒感染治疗中注意护肝治疗。
Objective To investigate whether biochemical indicators such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT) and other biochemical markers in determining human cytomegalovirus (HCMV) infection in children Reference value of liver cell injury. Methods Serum HCMV-DNA levels in 246 hospitalized children with HCMV infection were detected by fluorescence quantitative polymerase chain reaction (FQ-PCR) and divided into experimental group and control group. ALT, AST, GGT and other biochemical indicators. Results The cytotoxicity of ALT, AST and GGT in experimental group were higher than that in control group (P <0.05). Conclusions The elevated levels of hepatic functional enzymes such as ALT, AST and GGT may be valuable in judging the cytotoxicity of cytomegalovirus in patients with hepatocellular liver damage, suggesting that hepatoprotective therapy should be taken care in the treatment of cytomegalovirus infection.