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目的研究血清层粘蛋白（ＬＮ）和透明质酸（ＨＡ）对慢性肝病的诊断意义。方法检测急慢性肝炎及肝硬变患者血清ＬＮ和ＨＡ浓度，与肝功能及食管静脉曲张程度和肝脏病理进行比较。结果慢性肝炎血清ＬＮ明显高于健康者和急性肝炎，肝硬变患者血清ＬＮ升高幅度较大，是慢性肝炎（ＣＨ）患者的１．８倍（Ｐ＜０．０１）。ＨＡ以４００μｇ／Ｌ为界，ＬＮ以１５０μｇ／Ｌ为界，肝硬变同时升高者占８５．２％。ＣＨ则为９．７％，两组比较差异非常明显（Ｐ＜０．０１）。慢性丙型肝炎患者早期血清ＬＮ就显著升高，电镜观察发现丙型肝炎患者贮脂细胞及成纤维细胞增多，此种病理现象较ＣＨ患者明显。结论联合检测血清ＬＮ和ＨＡ对区分肝纤维化与肝硬变有意义
Objective To study the diagnostic value of serum laminin (LN) and hyaluronic acid (HA) in chronic liver disease. Methods Serum levels of LN and HA in patients with acute and chronic hepatitis and cirrhosis were detected and compared with those of liver function, esophageal varices and liver pathology. Results Serum LN in patients with chronic hepatitis was significantly higher than those in healthy controls and patients with acute hepatitis. Serum LN in patients with cirrhosis was significantly higher than that in patients with chronic hepatitis (CH) 1.8 times (P <0.01). 400μg / L for HA, 100μg / L for LN and 85.2% for cirrhosis. CH was 9.7%, the difference between the two groups was very significant (P <0.01). Serum LN was significantly increased in patients with chronic hepatitis C, and the number of storage fat cells and fibroblasts in patients with hepatitis C were increased by electron microscopy. This pathological phenomenon was more obvious in CH patients. Conclusion Combined detection of serum LN and HA is of great significance in distinguishing liver fibrosis from cirrhosis