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目的:探讨老年原发性高血压(EH)患者白细胞(WBC)、超敏C-反应蛋白(hs-CRP)、白细胞介素-18(IL-18)和纤维蛋白原(FIB)与动态脉压(PP)的相关性。方法:选取174例老年EH患者,采用动态血压监测仪测量受试者全天平均收缩压(SBP)、全天平均舒张压(DBP),并计算PP值,按照PP大小分为<60 mmHg(1mmHg=0.133kPa)组和≥60mmHg组,比较不同组间患者WBC、hs-CRP、IL-18与FIB的差异。结果:两组WBC、hs-CRP、IL-18与FIB均差异有统计学意义(均P<0.05);随着PP升高,WBC、hs-CRP、IL-18与FIB均呈升高趋势;WBC(r=0.224,P<0.01)、hs-CRP(r=0.169,P<0.05)、IL-18(r=0.166,P<0.05)与SBP呈正相关,WBC(r=0.181,P<0.05)、hs-CRP(r=0.259,P<0.01)、IL-18(r=0.245,P<0.05)、FIB(r=0.159,P<0.05)与PP呈正相关;hs-CRP(回归系数=0.119,OR=1.126)与IL-18(回归系数=0.005,OR=1.005)可能为PP的危险因素。结论:老年EH患者体内存在炎症反应,炎性因子参与了老年EH患者PP升高的病理生理学过程。
Objective: To investigate the relationship between WBC, hs-CRP, IL-18 and fibrinogen (FIB) and dynamic pulse in senile patients with essential hypertension (EH) Pressure (PP) correlation. Methods: One hundred and seventy-four elderly patients with EH were enrolled in this study. All-day mean systolic pressure (SBP) and mean daily diastolic pressure (DBP) were measured by ambulatory blood pressure monitor. PP values were calculated and divided into <60 mmHg 1mmHg = 0.133kPa) group and ≥ 60mmHg group. The differences of WBC, hs-CRP, IL-18 and FIB between different groups were compared. Results: There were significant differences in WBC, hs-CRP, IL-18 and FIB between the two groups (all P <0.05). The WBC, hs-CRP, IL- (R = 0.166, P <0.05) and WBC (r = 0.224, P <0.01) 0.05), hs-CRP (r = 0.259, P <0.01), IL-18 (r = 0.245, P <0.05) = 0.119, OR = 1.126) and IL-18 (regression coefficient = 0.005, OR = 1.005) may be risk factors for PP. Conclusion: Inflammatory reaction exists in elderly patients with EH, and inflammatory factors are involved in the pathophysiological process of elevated PP in elderly patients with EH.