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目的 为了解肠癌患者外周血(PB)中粘附分子(CD_(44))水平的临床意义。 方法 用流式细胞术检测了105例肠癌患者术前PB中CD_(44)水平和免疫细胞亚群,进行临床病理分析并与100例正常人PB中CD_(44)％作统计学处理比较。 结果 正常人PB中CD_(44)％为46.14±13.41,CD_(44)％与年龄、性别比较无统计学意义.直肠癌患者PB中CD_44％(54.17±16.62)与正常人比较差异有非常显著性(P<0.01),外生型癌患者PB中CD_(44)％(55.10±18.52)与正常人比较差异有非常显著性(P<0.01),肿瘤>4cm～8cm(53.48±16.97)和>9cm(63.67±12.99)患者PB中CD_(44)％与正常人比较差异有非常显著性(P<0.01),中分化腺癌患者PB中CD_(44)％(51.83±18.15)与正常人比较差异有显著性(P<0.05),低分化腺癌患者PB中CD_(44)％(58.31±14.66)与正常人比较差异有非常显著性(P<0.01),有淋巴结转移者PB中CD_(44)％(53±19.51)与正常人比较差异有显著性(P<0.05),DukesA+B期患者PB中CD_(44)％(51.09±15.83)与正常人比较差异有显著性(P<0.05),D期患者PB中CD_(44)％(63.93±13.9)与正常人比较差异有非常显著性(P<0.01),女性肠癌患者PB中CD_(44)％(55.07±17.17)与正常女性比较差异有非常显著性(P<0.01),<59岁肠癌患者PB中CD_(44)％(54.76±16.39)与正常人比较差
Objective To investigate the clinical significance of adhesion molecule (CD_ (44)) in peripheral blood (PB) of patients with colorectal cancer. Methods Flow cytometry was used to detect CD_ (44) levels and immune cell subsets in preoperative PB of 105 patients with colorectal cancer. The clinicopathological analysis was performed and compared with that of CD_ (44)% of PB in 100 healthy people . Results The percentage of CD_ (44)% in PB was 46.14 ± 13.41 in normal subjects, while the percentage of CD_ (44%) was no significant difference in age and sex.The difference of CD_44% (54.17 ± 16.62) in PB of rectal cancer patients was significant (P <0.01). There was a significant difference between CD44 (55.10 ± 18.52) and normal (P <0.01) in patients with exogenic carcinoma and in tumors> 4cm ~ 8cm (53.48 ± 16.97) and The CD_ (44)% of PB in> 9cm (63.67 ± 12.99) patients was significantly different from that in normal controls (P <0.01). CD_ (44)% (51.83 ± 18.15) The difference was significant (P <0.05). The difference of CD 44% (58.31 ± 14.66) in PB of poorly differentiated adenocarcinoma was significant compared with that in normal controls (P <0.01) (44)% (53 ± 19.51), there was a significant difference between the two groups (P <0.05). The percentage of CD 44% (51.09 ± 15.83) in PB of Dukes A + B patients was significantly different from that of normal people (P <0.01). The percentage of CD_ (44)% (55.07 ± 17.17)% in PB of female patients with colorectal cancer was significantly higher than that of normal patients (63.93 ± 13.9% Compared with normal women, the difference was significant (P <0.01), <59-year-old suffering from colorectal cancer (44)% PB in CD_ (54.76 ± 16.39) compared with normal difference