高血糖作为糖尿病主要代谢紊乱之一,在糖尿病并发症(DCC)的发生发展中发挥重要作用,现就其作用在分子机制上的研究进展综述如下:1　高血糖致DCC的四种学说1 1　多元醇通路(PP)增加　PP是机体正常糖代谢途径之一,由于该途径限速酶醛糖还原酶(AR)正常情况下对葡萄糖亲和力低,故 As one of the major metabolic disorders of diabetes mellitus, hyperglycemia plays an important role in the occurrence and development of diabetic complications (DCC). The progress on the molecular mechanisms of hyperglycemia is summarized as follows: 1 Four theories of hyperglycemia induced DCC 1 1 Polyol pathways (PP) increase PP is one of the normal glucose metabolism pathways in the body. Due to its low affinity to glucose under normal circumstances, the rate-limiting enzyme aldose reductase (AR)