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本文应用辛伐他汀对 36例Ⅱ型糖尿病伴高脂血症患者进行了为期 1 2周短期观察。结果显示 :辛伐他汀明显降低血胆固醇、甘油三酯及低密度脂蛋白胆固醇 (4 4 2± 1 33mmol/L比 3 0 1± 0 98mmol/L) ,明显升高高密度脂蛋白胆固醇 (P均 <0 0 5) ;同时明显升高血浆纤溶酶原激活物活性和降低血浆纤溶酶原激活物抑制 -1活性 ,P <0 0 5,上述指标的变化不依赖血糖控制的改变。提示辛伐他汀可明显改善糖尿病患者异常的脂质代谢和纤溶障碍 ,对糖尿病患者加速的动脉硬化性疾病的防治有较好的作用
In this paper, 36 patients with type 2 diabetes with hyperlipidemia were treated with simvastatin for a short period of 12 weeks. The results showed that simvastatin significantly reduced blood cholesterol, triglycerides and LDL cholesterol (442 ± 1 33mmol / L vs 301 ± 98mmol / L) and significantly increased high density lipoprotein cholesterol All <0 05). At the same time, the activities of plasma plasminogen activator and plasminogen activator inhibitor-1 were significantly increased (P <0.05). The changes of these indexes were independent of the changes of glycemic control. Prompted that simvastatin can significantly improve the abnormal lipid metabolism and fibrinolytic disorders in patients with diabetes, and accelerated the prevention and treatment of arteriosclerosis in patients with diabetes have a better effect