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目的:研究食管黏膜上皮内瘤变患者症状特点、频率及其与疾病范围的关系.方法:选择2009-01/2009-12因食管黏膜上皮内瘤变来南京大学医学院附属鼓楼医院行内镜下黏膜切除术(EMR)的患者,对他们进行问卷调查,建立信息库,并对结果进行统计分析.结果:101例食管黏膜上皮内瘤变患者中男71例,女30例.101例患者中有42例(41.58%)患者存在反酸、嗳气症状,28例(27.72%)患者有胸痛,仅3例(2.97%)患者无症状.多数患者发生上述症状频率为2-3d/周,食管黏膜切除术后病理结果显示,高级别上皮内瘤变35例,低级别上皮内瘤变54例,癌变12例.病变位于中段的患者发生反流症状较病变位于下段和上段者更多(P<0.001).结论:食管黏膜上皮内瘤变患者有反流相关症状,而且与病变发生部位有一定相关性,临床上应重视并对具有这类症状的患者进行全面的内镜检查.
Objective: To study the characteristics, frequency and the relationship between the symptoms and the extent of disease in patients with esophageal intraepithelial neoplasia.Methods: The endoscopic diagnosis of esophageal mucosal intraepithelial neoplasia (MND) from 2009 to 2009 in Gulou Hospital Affiliated to Nanjing University (EMR) patients were surveyed, the establishment of a database, and the results of a statistical analysis.Results: 101 cases of esophageal mucosal intraepithelial neoplasia in 71 males and 30 females in 101 cases In 42 (41.58%) patients, there were symptoms of acid reflux and belching, chest pain in 28 patients (27.72%) and asymptomatic in only 3 patients (2.97% Pathological findings of esophageal mucosal resection showed that 35 cases of high grade intraepithelial neoplasia, 54 cases of low grade intraepithelial neoplasia, and 12 cases of cancerous lesions.The reflux symptoms in the middle stage of patients were more than those in the lower and upper stages P <0.001) .Conclusion: There are reflux-related symptoms in patients with esophageal intraepithelial neoplasia, and there is a certain correlation with the site of lesion, which should be paid attention to in clinic and comprehensive endoscopy should be performed in patients with such symptoms.