氨茶碱是存在生物有效性差异、需要进行生物利用度测定的药物品种~[1,2]。通过对具有速释层和缓释层的双层复方长效氨茶碱片生物利用度的研究,可以考察该制剂的质量情况,为进一步改进工艺、确保产品质量,提高生物有效性提供参考依据。本实验对复方长效氨茶碱片的体外释放度和兔体内生物利用度进行了测定,对T_(50)进行了方差分析,并对体内外参数进行了相关性统计,现将结果简介如下: Aminophylline is a drug that has bioavailability differences and requires bioavailability measurement [1,2]. By studying the bioavailability of the double-layered compound long-acting aminophylline tablets with immediate-release layer and sustained-release layer, the quality of the preparation can be investigated to provide a reference for further improving the process, ensuring the product quality and improving the bioavailability . In this study, in vitro release of compound long-acting aminophylline tablets and bioavailability in rabbits were determined, the T_ (50) were analyzed by variance, and in vitro and in vivo parameters were statistics, the results are summarized as follows :