心肌细胞膜(肌膜)为一半通透性界膜,心肌细胞通过它与周围环境发生复杂的联系,选择性地进行物质交换。肌膜的完整性对维持心肌细胞的功能十分重要。近年一些研究表明,肌膜通透性增大常是心肌细胞遭受损伤的一个早期特征。在克山病病因研究中,人们已开始注意心肌细胞膜通透性变化在克山病心肌坏死发生机制中的作用,但迄今尚未见到有关的实验研究资料。本实验研究以辣根过氧化物酶(HRP)作示踪物,研究喂饲克山病病区粮的大白鼠心肌细胞膜通透性的变化。 Myocardial membrane (sarcolemma) is half of the permeability of the membrane, myocardial cells through its complex relationship with the surrounding environment, the selective exchange of material. The integrity of the sarcolemma is important in maintaining the function of the cardiomyocytes. In recent years, some studies have shown that increased permeability of the sarcolemma is often an early feature of myocardial cell injury. In the etiology of Keshan disease, people have begun to pay attention to changes in myocardial cell membrane permeability in the pathogenesis of Keshan myocardial necrosis, but so far have not seen the relevant experimental data. In this study, horseradish peroxidase (HRP) was used as a tracer to study the changes of membrane permeability in rat myocardial cells fed with Keshan disease.