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目的探讨原发性肝癌患者血清瘦素水平及其异常变化的临床意义。方法选择64例原发性肝癌患者和59例与其在性别、年龄和体重指数(BMI)相匹配的对照者,应用ELISA方法检测血清瘦素水平,同步检测肝功能和血脂,肝癌患者测定甲胎蛋白,对血清瘦素、血脂与肝功能的关系进行分析。结果肝癌组与对照组相比血清瘦素水平无差异;与正常对照组相比,肝癌患者CHO、LDL水平显著降低,差异有显者性。去除腹水因素,无腹水肝癌患者血清瘦素水平与BMI及Fat%均呈显著正相关,与肝功能、甲胎蛋白无关。结论血清瘦素水平不能作为原发性肝癌患者肝功能的预测指标,血脂是肝功能减退的指标。瘦素可能参与了肝癌患者的营养不良。
Objective To investigate the clinical significance of serum leptin level and its abnormal changes in patients with primary liver cancer. Methods Sixty-four patients with primary liver cancer and 59 controls matched for gender, age and body mass index (BMI) were enrolled in this study. Serum leptin level was measured by ELISA. Simultaneous detection of liver function and blood lipids, Protein, serum leptin, blood lipids and liver function analysis. Results Compared with the control group, there was no difference in serum leptin level between the HCC group and the control group. Compared with the normal control group, the levels of CHO and LDL in the HCC patients significantly decreased, with a significant difference. Removal of ascites, serum ascites levels of serum leptin and BMI and Fat% were significantly correlated positively with liver function, alpha-fetoprotein unrelated. Conclusion Serum leptin level can not be used as a predictor of liver function in patients with primary liver cancer. Lipid is an indicator of liver dysfunction. Leptin may be involved in malnutrition in patients with liver cancer.