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目的：以进口依那普利进行临床对比研究，评价国产盐酸苯那普利的降压疗效和安全性。方法：盐酸苯那普利和依那普利随机、单盲治疗轻、中度Ⅰ、Ⅱ期原发性高血压患者４０ 例，剂量均为１０ ｍ ｇ／ｄ，治疗２ 周后必要时均加氢氯噻嗪２５ ｍ ｇ／ｄ。观察苯那普利短期（４ 周）及长期（６ 个月）治疗的效果、动态血压变化及不良反应。结果：①苯那普利和依那普利治疗４ 周末的显效率及总有效率分别为６０．０％ 、５０．０％ 及７５．０％ 、７０．０％ ，组间无显著性差异；②苯那普利服用６ 个月的患者降压疗效与服药４ 周时相同，无耐药性出现；③１０ ｍ ｇ／ｄ 苯那普利组治疗４ 周后２４ ｈ 血压监测收缩压和舒张压的谷－峰比值分别为７１．９％ 和５５．１％ ，均＞ ５０％ ；④苯那普利组出现不良反应的发生率为１５．０％ （３／２０），依那普利组２０．０％ （４／２０）。结论：国产苯那普利治疗轻、中度原发性高血压的近期及长期疗效显著，每日１ 次给药效果持久、稳定，不良反应轻。
OBJECTIVE: To compare the clinical efficacy of enalapril hydrochloride with imported enalapril and evaluate the antihypertensive efficacy and safety of domestic benazepril hydrochloride. Methods: Benazepril hydrochloride and enalapril were randomized, single-blind treatment of mild and moderate stage Ⅰ, Ⅱ 40 patients with essential hypertension, the dose was 10 m g / d, after 2 weeks of treatment if necessary Hydrochlorothiazide 25 m g / d. The effects of short-term (4 weeks) and long-term (6 months) benazepril treatment, ambulatory blood pressure changes, and adverse reactions were observed. Results: (1) The markedly effective rate and total effective rate of benazepril and enalapril at the end of 4 weeks were 60.0%, 50.0%, 75.0% and 70.0%, respectively. There was no significant difference between the two groups. ② The antihypertensive efficacy of benazapril in patients who took 6 months was the same as that of 4 weeks after taking benazepril. ③ The blood pressure was monitored 24 hours after 10 m g / d benazepril treatment. Systolic and diastolic blood pressure The peak-to-peak ratios were 71.9% and 55.1% respectively, all of which were> 50%. ④ The incidence of adverse reactions in the benazepril group was 15.0% (3/20) 20.0% (4/20). Conclusion: Domestic benazepril treatment of light and moderate essential hypertension in the short term and long - term effect is obvious, once a day administration lasting effect, stability, adverse reactions.