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目的研究苯磺酸氨氯地平(商品名络活喜)和谷胱甘肽(商品名阿拓莫兰)对体外冲击波碎石术(ESWL)所致肾功能损害的保护作用。方法接受ESWL治疗的肾结石患者104例,随机分为阿拓莫兰组,络活喜组,联合组和对照组,每组26例。检测ESWL前1d和后1、3、7d尿丙二醛(MDA)、N-乙酰-β-D-氨基葡萄糖苷酶/肌酐(NAG/Cr)和24h尿β2-微球蛋白(β2-MG)的变化。结果所有治疗组尿NAG/Cr、MDA及24h尿β2-MG水平均明显低于对照组,肾功能恢复较快。结论 ESWL所致的肾损伤与自由基有关,钙离子拮抗剂有减轻脂质过氧化的作用,与阿拓莫兰合用明显保护肾脏,减轻ESWL所引起的肾损伤。
Objective To study the protective effect of amlodipine besylate (API) and glutathione (APO) on renal dysfunction induced by extracorporeal shock wave lithotripsy (ESWL). Methods A total of 104 patients with ESWL were randomly divided into two groups: metoprolol group, Luohuoxue group, combination group and control group, with 26 cases in each group. Urine malondialdehyde (MDA), N-acetyl-β-D-glucosaminidase / creatinine (NAG / Cr) and 24h urinary β2-microglobulin (β2-MG )The change. Results The urinary NAG / Cr, MDA and urinary β2-MG levels in all treatment groups were significantly lower than those in the control group, and renal function recovered quickly. Conclusions ESWL - induced renal injury is related to free radicals. Calcium antagonists can reduce lipid peroxidation. Combination with exenatide can obviously protect the kidneys and alleviate the renal damage caused by ESWL.