细胞色素P450(CYPs)酶是一种多功能酶系,是生物体内参与内源性化合物(激素、脂肪酸)和外源性化合物(药物、前致癌物和前毒物)主要生物转化的酶系。CYPs为整个酶系中的末端氧化酶,不仅负责活化氧分子,同时负责与底物结合,并决定酶系底物的专一性,在整个酶系功能中起着尤为关键的作用。目前,大约有1000种已知的细胞色素P450,这些已知的细胞色素P450能够分成17个家族(如: Cytochrome P450 (CYPs) is a versatile enzyme system that is involved in the major biotransformations of endogenous compounds (hormones, fatty acids) and exogenous compounds (drugs, pro-carcinogens and pre-poisons) in the body. CYPs, the terminal oxidase in the whole enzyme system, are not only responsible for the activation of oxygen molecules, but also responsible for binding to substrates and determining the specificity of enzyme substrates, playing a key role in the enzyme function. There are about 1,000 known cytochrome P450s that can be divided into 17 families (eg,