论文部分内容阅读
目的研究2型糖尿病患者炎性因子与血糖控制质量的关系。方法选择临床确诊的2型糖尿病患者160例,其中男性84例,女性76例;年龄42~73岁,平均年龄63.50岁。根据血糖控制程度分为2组:血糖控制良好组(92例)和血糖控制不良组(68例)。同时选择100例健康人为对照组,其中男性55例,女性45例;年龄45~75岁,平均年龄62.80岁。所有参与者的细胞因子——白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、白细胞介素8(IL-8)浓度应用液体芯片方法检测。结果糖尿病组IL-6、TNF-α、IL-8均显著高于对照组(P<0.01),且血糖控制不良组IL-6、TNF-α、IL-8亦显著高于血糖控制良好组(P<0.01)。但IL-1β浓度在对照组与糖尿病组间差异无统计学意义,且与血糖控制程度无关。结论糖尿病患者的细胞因子处于低级别炎症状态,且血糖控制影响炎症水平。
Objective To study the relationship between the inflammatory factors and the quality of blood sugar control in type 2 diabetic patients. Methods A total of 160 clinically diagnosed Type 2 diabetic patients were selected, including 84 males and 76 females, aged from 42 to 73 years with an average age of 63.50 years. Divided into two groups according to the degree of glycemic control: good glycemic control group (92 cases) and poor glycemic control group (68 cases). At the same time, 100 healthy people were chosen as the control group, including 55 males and 45 females, aged from 45 to 75 years old, with an average age of 62.80 years. The concentrations of IL-6, TNF-α, IL-1β and IL-8 in all participants were calculated using liquid Chip detection method. Results The levels of IL-6, TNF-α and IL-8 in diabetic group were significantly higher than those in control group (P <0.01), and the levels of IL-6, TNF-α and IL-8 in DM group were significantly higher than those in DM group (P <0.01). However, there was no significant difference in IL-1βconcentration between the control group and diabetic group, and had no relation with the degree of glycemic control. Conclusion The cytokines in diabetic patients are in a low-grade inflammatory state and the blood glucose control affects the level of inflammation.