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目的观察米索前列醇和缩宫素预防剖宫产出血的效果。方法240例剖宫产产妇随机分为A组:米索前列醇400μg舌下含服;B组:缩宫素静脉及宫体各注射20U;C组:米索前列醇400μg舌下含服加缩宫素宫体20U注射。观察各组术中、术后24h出血量,手术前后Hb及HCT的变化。结果三组术中出血量:A组与其余两组相比,差异有显著性。术中失血≥500m,l三组分别是25%,5%,2.5%,有显著性差异。产前产后Hb、HcT变化三组间无明显差异。结论单纯舌下含服米索前列醇400μg预防剖宫产术中出血的效果不及米索前列醇加缩宫素和单独使用缩宫素组,单独使用缩宫素预防剖宫产术后出血的效果不及米索前列醇加缩宫素组和米索前列醇组,米索前列醇加缩宫素预防剖宫产术中和术后出血的效果最佳。
Objective To observe the effect of misoprostol and oxytocin in preventing cesarean section bleeding. Methods 240 cesarean section women were randomly divided into group A: misoprostol 400μg sublingual; group B: oxytocin intravenous and uterine injection of 20U; group C: misoprostol 400μg sublingual administration Palace oxytocin 20U injection. Observe the intraoperative and postoperative 24h blood loss, Hb and HCT changes before and after surgery. Results Three groups of intraoperative blood loss: A group compared with the other two groups, the difference was significant. Intraoperative blood loss ≥ 500m, l three groups were 25%, 5%, 2.5%, a significant difference. Prenatal postpartum changes in Hb, HcT no significant difference between the three groups. Conclusion The sublingual administration of misoprostol 400μg is less effective than misoprostol plus oxytocin and oxytocin alone in the prevention of bleeding during cesarean section. Oxytocin alone can prevent bleeding after cesarean section The effect is less than misoprostol plus oxytocin group and misoprostol group, misoprostol plus oxytocin to prevent cesarean section and postoperative bleeding the best.