一氧化氮(NO)在调节肺的某些生物功能中起着重要作用,包括对肺动脉和支气管平滑肌张力的调节。近来研究已证明,在动物模型中,吸入相对高浓度的NO能减少乙酰甲胆碱的支气管收缩作用。这为NO吸入作为选择性支气管扩张剂提供了应用前景。虽然在成人气道反应性或支气管哮喘患者中,这种治疗作用的研究已有报道,但关于NO在儿童哮喘人群中的应 Nitric oxide (NO) plays an important role in the regulation of certain biological functions of the lung, including regulation of pulmonary artery and bronchial smooth muscle tone. Recent studies have demonstrated that inhalation of relatively high concentrations of NO reduces the bronchoconstriction of methacholine in animal models. This provides a promise for NO inhalation as a selective bronchodilator. Although studies of this therapeutic effect have been reported in adults with airway responsiveness or bronchial asthma, the role of NO in childhood asthma should be