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目的:采用Beagle犬致敏实验研究来评价鱼腥草注射液新制剂(new Houttuynia Cordata injec-tion,NYI)的致敏性。方法:在类过敏和过敏试验中,通过静脉注射不同剂量的NYI,观察给药后Beagle犬的行为学变化,检测血浆中组胺、IgE的含量变化。结果:NYI在致敏给药后未出现明显的行为异常,类过敏试验中血浆组胺和IgE升高不明显,在过敏试验中血浆组胺和IgE未见升高。结论:NYI对Beagle犬未发现有明显的过敏性反应,为临床安全用药提供了实验依据。
OBJECTIVE: To evaluate the allergenicity of new Houttuynia Cordata in vitro (NYI) using Beagle dog sensitization experiments. METHODS: In the allergy and allergy test, different doses of NYI were injected intravenously to observe the behavioral changes of Beagle dogs after administration and to detect changes in histamine and IgE levels in plasma. RESULTS: NYI did not show significant behavioral abnormalities after sensitization administration. Plasma histamine and IgE levels did not increase significantly in anaphylaxis trials, and plasma histamine and IgE levels did not increase during allergy tests. Conclusion: NYI has no obvious allergic reaction to Beagle dogs, providing experimental basis for clinical safe drug use.