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目的评价妊娠中期孕妇血清(AFP/Free-β-hCG)二联法筛查在唐氏综合征、18-三体综合征和神经管缺陷的临床应用价值。方法采用双标记时间分辨荧光法对9338例孕周15～20+6周的孕妇进行血清AFP和Free-β-hCG浓度的检测,并结合孕周、体重、年龄等因素,通过风险评估软件进行风险评估。结果 9338例孕中期孕妇中,阳性率为4.7%(437/9338)。筛查出唐氏综合征高风险262例,阳性率2.8%,神经管缺陷高风险119例,阳性率1.3%,18-三体高风险56例,阳性率0.6%。结论利用孕妇孕中期两种血清标志物的检测对孕妇进行产前筛查可以有效地降低缺陷儿的出生率。
Objective To evaluate the clinical value of dual screening of pregnant women ’s serum in the second trimester of pregnancy (AFP / Free-β-hCG) in Down’s syndrome, 18-trisomy and neural tube defects. Methods The serum concentration of AFP and Free-β-hCG in 9338 pregnant women with gestational age of 15-20 + 6 weeks were detected by double-labeled time-resolved fluorescence spectrometry. Combined with gestational age, weight, age and other factors, risk assessment software Risk assessment. Results 9338 pregnant women in the second trimester, the positive rate was 4.7% (437/9338). The high risk of Down syndrome was detected in 262 cases, the positive rate was 2.8%, the high risk of neural tube defects in 119 cases, the positive rate of 1.3%, 56 cases of 18-trisomy 56, the positive rate of 0.6%. Conclusion The detection of two serum markers in pregnant women during the second trimester can reduce the birth rate of defective children effectively.