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目的:观察盐酸格拉司琼联合甲基强的松龙(甲强龙)的止吐效果。方法:将52例接受顺铂化疗的患者,随机分为两组,即单剂盐酸格拉司琼和盐酸格拉司琼加甲强龙组,采用交叉对比的方法,比较单剂盐酸格拉司琼和盐酸格拉司琼加甲强龙联用的疗效。结果:单剂盐酸格拉司琼对呕吐的完全控制率为80.7%,盐酸格拉司琼加甲强龙联用则为92.3%,两组比较差异显著,P<0.01。结论:盐酸格拉司琼与甲强龙联用可显著改善顺铂引起的急性呕吐。
Objective: To observe the antiemetic effect of granisetron hydrochloride combined with methylprednisolone (methylprednisolone). Methods: Fifty-two patients receiving cisplatin chemotherapy were randomly divided into two groups: single granisetron hydrochloride and granisetron plus methylprednisolone group. Cross-contrast method was used to compare single-dose granisetron hydrochloride and The efficacy of granisetron hydrochloride plus methylprednisolone combined. Results: The complete control rate of single dose granisetron hydrochloride on vomiting was 80.7%, while that of granisetron plus methylprednisolone hydrochloride was 92.3%. There was significant difference between the two groups (P <0.01). Conclusion: Granisetron hydrochloride and methylprednisolone can significantly improve cisplatin-induced acute vomiting.