论文部分内容阅读
目的研究结核患者细胞因子变化规律和调控机制,以帮助临床鉴别诊断。方法对54例结核患者、18例肺癌患者和12例健康人血清、肺泡灌洗液、胸水及脑脊液等多种标本的各种细胞因子进行检测。结果结核患者血清白介素(IL)-12、IL-18等T h1细胞因子及IL-10、IL-4等T h2细胞因子水平均较高。各种细胞因子在脑脊液中含量均较低;干扰素γ(IFN-γ)在胸水渗出液中含量很高。前炎性因子IL-6、IL-8和肿瘤坏死因子-α(TNF-α)在结核患者中水平较高。IL-10与TNF-α的比值在结核和肿瘤患者之间有显著差异。结论细胞因子检测有助于结核病和肺癌患者的鉴别诊断。
Objective To study the change rules and regulatory mechanisms of cytokines in tuberculosis patients in order to help clinical differential diagnosis. Methods Various cytokines were detected in serum, bronchoalveolar lavage fluid, pleural effusion and cerebrospinal fluid in 54 cases of tuberculosis, 18 cases of lung cancer and 12 cases of healthy people. Results T h1 cytokines such as interleukin (IL) -12 and IL-18, and T h2 cytokines such as IL-10 and IL-4 were significantly higher in tuberculosis patients. A variety of cytokines in cerebrospinal fluid were low; interferon γ (IFN-γ) in pleural effusion in high levels. The proinflammatory cytokines IL-6, IL-8 and tumor necrosis factor-α (TNF-α) are elevated in patients with tuberculosis. The ratio of IL-10 to TNF-α is significantly different between tuberculosis and cancer patients. Conclusion The detection of cytokines is helpful for the differential diagnosis of tuberculosis and lung cancer patients.