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１９９３年是ＷｉｌｌｉａｍＣｏｌｅｙ首次报道“细菌毒素激活的免疫系统诱导肿瘤消退”的１００周年。而当许多相继而来的癌症疫苗试验已经得到撩拨人心的结果时，主动的免疫治疗仍没有成为确定的癌症疗法。新的分子疫苗方法基于合理的免疫学原理之上，增进了动物模型中的系统抗肿瘤效应，最终，肿瘤特异性抗原的遗传确定将使用于癌症治疗的靶抗原特异性疫苗得到发展。
In 1993, William Coley reported for the first time that the “Bacterial toxin-activated immune system induced tumor regression” was 100 years old. When many of the successive cancer vaccine trials have been well-received, active immunotherapy has not yet become definitive cancer therapy. The new molecular vaccine approach is based on rational immunological principles that enhance the systemic anti-tumor effects in animal models. Finally, the genetic identification of tumor-specific antigens will be used to develop targeted antigen-specific vaccines for cancer treatment.