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目的探讨多囊卵巢综合征(PCOS)患者外周血白细胞(WBC)计数与体质量指数(BMI)、总睾酮(T)、雌二醇(E2)和促黄体生成素(LH)的关系。方法对1 016例PCOS患者(PCOS组)和1 016例正常女性(对照组)的人体测量研究结果和基础内分泌指标进行回顾性分析,比较两组外周血WBC总数及其分类中性粒细胞(N)和淋巴细胞(L)计数,并分析PCOS患者外周血WBC总数及其分类N、L计数与BMI、T、E2、LH的相关性。结果PCOS患者的外周血WBC总数和L计数明显高于正常女性(P<0.05),WBC总数和L计数的升高与PCOS患者的BMI增加有关,与高水平E2和高水平LH不相关(P>0.05),WBC总数的升高与T呈正相关性(r=0.073,P<0.05),L计数的升高与T不相关(P>0.05)。结论 PCOS患者的WBC总数和淋巴细胞计数明显高于正常女性。
Objective To investigate the relationship between peripheral white blood cell (WBC) counts and body mass index (BMI), total testosterone (T), estradiol (E2) and luteinizing hormone (LH) in women with polycystic ovary syndrome (PCOS). Methods The anthropometric results and basic endocrine indexes of 1 016 PCOS patients (PCOS group) and 1 016 healthy women (control group) were retrospectively analyzed. The number of WBC in peripheral blood and the percentage of neutrophils N and lymphocyte counts in patients with PCOS. The correlation between WBC count, N, L count and BMI, T, E2, LH in PCOS patients was analyzed. Results The WBC count and L count of peripheral blood in patients with PCOS were significantly higher than those in normal women (P <0.05). The increase of WBC count and L count was related with the increase of BMI in patients with PCOS, but not with high level of E2 and high level of LH > 0.05). The increase of total WBC was positively correlated with T (r = 0.073, P <0.05). The increase of L count was not correlated with T (P> 0.05). Conclusions The WBC counts and lymphocyte counts in patients with PCOS are significantly higher than those in normal women.