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肝脏是胎儿2~5个月时产生红细胞的主要器官, 出生后肝脏与造血功能仍有密切关系,许多造血物质如蛋白质由肝合成,维生索B_(12)和叶酸贮存在肝内,多种凝血因子亦在肝内合成。肝病时,由于贮存及合成功能障碍,故可引起贫血。据报导,肝病患者合并贫血达77%。其中大细胞性贫血占32.6%,小细胞性贫血占14.4%,正常细胞性者占30.3%,余为混合性贫血。肝病引起的贫血可分为两大类,即肝病本身引起和肝病的并发症引起。一、肝病本身引起的贫血 1.肝病营养性贫血:有人测定肝硬变时B_(12)含量约为正常人的40%;并证明80%慢性肝病患者有血清叶酸浓度的明显降低,而且此类病人尿叶酸排出量增加。叶酸缺乏可引起大细胞性贫血。
The liver is the main organ for producing erythrocytes 2 to 5 months after birth. The liver after birth is still closely related to the hematopoietic function. Many hematopoietic substances, such as protein, are stored in the liver by liver synthesis, vitronectin B 12 and folic acid Blood coagulation factors are also synthesized in the liver. Liver disease, due to storage and synthesis dysfunction, it can cause anemia. It is reported that patients with liver disease with anemia up to 77%. Including large cell anemia accounted for 32.6%, small cell anemia accounted for 14.4%, 30.3% of normal cells, the remaining mixed anemia. Anemia caused by liver disease can be divided into two categories, namely liver disease itself caused by complications caused by liver disease. First, the liver itself caused by anemia 1. Liver Nutritional anemia: Some people determine the cirrhosis B_ (12) content of about 40% of normal; and prove that 80% of patients with chronic liver disease serum folate concentration was significantly lower, and this Uric acid in patients with urinary output increased. Folic acid deficiency can cause large cell anemia.