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目的:实验观察半夏白术天麻汤化裁方对高血脂模型大鼠相关指标的影响,为临床用药提供药效学依据。方法:给予大鼠高脂饲料4周,造成高血脂大鼠模型,同时给予受试药半夏白术天麻汤化裁方,测定给药过程中大鼠体重变化及给药后高脂模型大鼠甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(apoA1)、载脂蛋白B(apoB),超氧化物歧化酶(SOD),丙二醛(MDA)的变化。结果:半夏白术天麻汤化裁方3个剂量组体重与模型组比较,高剂量组体重较同期模型对照组比较有所增加。半夏白术天麻汤化裁方3个剂量组对血清甘油三酯均具有显著地降低作用,高剂量组对血清CHOL,LDL水平亦具有显著地降低作用,与模型组比较具有显著性差异(P<0.05)。半夏白术天麻汤化裁方3个剂量组能不同程度提高血清HDL水平,但与模型组比较无显著性差异。各组大鼠血清apo A1水平均无显著性差异,各剂量组和血脂康对照组不同程度降低apo B水平,其中半夏白术天麻汤化裁方高剂量组最为明显。半夏白术天麻汤化裁方3个剂量组不同程度提高SOD活性,降低MDA含量,其中以高剂量作用最为明显。结论:半夏白术天麻汤化裁方具有明确的改善高血脂相关指标的作用。
OBJECTIVE: To observe the effect of Banxiabaizhutianma Decoction on hyperlipidemia-related indicators in rats and provide pharmacodynamic basis for clinical use. Methods: The rats were given high-fat diet for 4 weeks, resulting in hyperlipidemic rat model, meanwhile given the Banxiabaizhu Tianma Decoction of the tested drug. The body weight of the rats was measured during the administration, TG, CHOL, HDL, LDL, apoA1, apoB and superoxide dismutase (SOD) SOD), malondialdehyde (MDA) changes. Results: Compared with the model group, the body weight of Banxiabaizhu Tianma Tangmai Recipe group had increased compared with the model group, the body weight of high dose group increased compared with the model control group. Banxiabaizhu Tianma Tangmai Recipe 3 doses of serum triglyceride were significantly reduced, high-dose group of serum CHOL, LDL levels also had a significant effect, compared with the model group had significant differences (P <0.05). Pineel Atractylodes Tianma Decoction 3 doses of serum levels can increase the level of serum HDL, but compared with the model group no significant difference. Serum apo A1 levels of rats in each group had no significant difference, each dose group and Xuezhikang control group decreased apo B levels to varying degrees, of which Pinellia Atractylodes Tianma Decoction high-dose group was the most obvious. Pinellia Atractylodes Tianma Decoction 3 doses of different levels to improve SOD activity, reduce MDA content, of which the role of high doses of the most obvious. Conclusion: Banxiabaizhu Tianma Decoction has a clear improvement in hyperlipidemia-related indicators.