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目的研究复发性单纯疱疹性角膜炎患者血清白细胞介素-2（IL－2）及其可溶性白细胞介素-2受体（SIL－2R）水平。方法本文测定了30例复发性单纯疱疹性角膜炎患者（实验组）和25例健康人（对照组）血清白细胞介素－2（IL－2）及其可溶性白细胞介素－2受体（SIL－2R）的水平。结果对照组IL－2的水平为5．41±1．45mg·L－1，实验组IL－2R水平为2．80±1.47mg·L-1,2组比较t＝2．90，P＜0．01，说明复发性单纯疱疹性角膜炎患者血清IL－2水平较对照组明显降低。对照组SIL－2R水平为90．86±17．90mg·L－1，实验组SIL－2R水平为171·46±19.30mg·L－1，2组比较t＝5．17，P＜0．01。复发性单纯疱疹性角膜炎患者血清SlL－2R水平较对照组显著升高。结论复发性单纯疱疹性角膜炎患者体内免疫功能紊乱，血清IL－2活性降低、SlL－2R水平升高可能是其原因之一，这也为免疫治疗提供了一定依据。
Objective To study the levels of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) in patients with recurrent herpes simplex keratitis. Methods Thirty patients with recurrent herpes simplex keratitis (experimental group) and 25 healthy subjects (control group) were enrolled in this study. Serum interleukin-2 (IL-2) and soluble interleukin-2 receptor -2R) levels. Results The level of IL-2 in control group was 5.41 ± 1.45 mg · L-1, the level of IL-2R in experimental group was 2.80 ± 1.47 mg · L-1, compared with t = 2.90, P < 0.01, indicating that patients with recurrent herpes simplex keratitis serum IL-2 levels were significantly lower than the control group. The level of SIL-2R in the control group was 90.86 ± 17.90mg · L-1, the level of SIL-2R in the experimental group was 171 · 46 ± 19.30mg · L-1, compared with t = 5.17, P <0. 01. Serum SlL-2R levels in patients with recurrent herpes simplex keratitis were significantly higher than those in the control group. Conclusion In patients with recurrent herpes simplex keratitis, immune function disorder, decreased serum IL-2 activity and elevated S1L-2R levels may be one of the reasons. This may provide a basis for immunotherapy.