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目的探讨血清中可溶性上皮钙黏附蛋白(sE-CD)的浓度在胃癌诊断及复发中的意义。方法用酶联免疫吸附试验测定25例正常人,65例胃癌患者术前末作任何治疗,术后1周无感染血清中sE-CD的浓度,研究其浓度与胃癌的临床、病理的关系。同时测定肿瘤特异性生长因子(TSGF)及血清癌胚抗原(CEA)作对照。结果胃癌患者血清中sE-CD比正常对照组明显增高,差异有统计学意义(P＜0．05)；术前,术后血清中sE-CD浓度比较差异有统计学意义(P＜0．05),术后血清sE-CD浓度下降。结论sE-CD有望成为胃癌的早期诊断及判定复发的指标。
Objective To investigate the significance of serum sE-CD in the diagnosis and recurrence of gastric cancer. Methods Serum levels of sE-CD were measured in 25 normal individuals and 65 patients with gastric cancer by enzyme-linked immunosorbent assay (ELISA). The relationship between the concentration of sE-CD and the clinical and pathological features of gastric cancer was studied. Tumor specific growth factor (TSGF) and serum carcinoembryonic antigen (CEA) were measured simultaneously. Results The serum levels of sE-CD in patients with gastric cancer were significantly higher than those in normal controls (P <0.05). The levels of sE-CD in preoperative and postoperative serum were significantly different (P <0. 05), postoperative serum sE-CD decreased. Conclusion sE-CD is expected to become an indicator of early diagnosis and recurrence of gastric cancer.