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目的:探讨中性鱼精蛋白锌胰岛素,甘精胰岛素及地特胰岛素应用方案治疗口服降糖药物血糖控制不佳2型糖尿病临床疗效及安全性差异。方法:研究对象选取我院2012年3月-2015年6月收治行口服降糖药物血糖控制不佳2型糖尿病患者共150例,以随机区组法分为A组,B组及C组,每组各50例,分别采用中性鱼精蛋白锌胰岛素,甘精胰岛素及地特胰岛素应用方案治疗,比较三组患者治疗前后血糖指标水平、胰岛素用量及低血糖发生率等。结果:三组患者治疗后血糖指标水平显著低于治疗前,差异有统计学意义(P<0.05);三组患者治疗后血糖指标水平比较差异无统计学意义(P>0.05);A组患者胰岛素用量显著多于B组、C组,差异有统计学意义(P<0.05);A组患者低血糖发生率显著高于B组、C组,差异有统计学意义(P<0.05)。结论:三种胰岛素应用方案治疗口服降糖药物血糖控制不佳2型糖尿病临床疗效接近,但甘精胰岛素和地特胰岛素应用可有效减少胰岛素用量,降低低血糖发生风险。
Objective: To investigate the clinical efficacy and safety of neutral protamine zinc insulin, insulin glargine and insulin detemir application in the treatment of type 2 diabetes with poor glycemic control. Methods: Selected 150 cases of type 2 diabetes mellitus patients with poor glycemic control in our hospital from March 2012 to June 2015 were randomly divided into A group, B group and C group, Each group of 50 cases, respectively, the use of neutral protamine zinc insulin, insulin glargine and insulin treatment program application, the three groups before and after treatment, blood glucose levels, insulin dosage and incidence of hypoglycemia. Results: The blood glucose level of the three groups after treatment was significantly lower than that before treatment (P <0.05). There was no significant difference in the level of blood glucose between the three groups after treatment (P> 0.05) The dosage of insulin was significantly more than that of group B and C (P <0.05). The incidence of hypoglycemia in group A was significantly higher than that of group B and C (P <0.05). CONCLUSION: The clinical efficacy of the three insulin regimens in treating type 2 diabetes with poorly controlled blood glucose control is similar, but the use of insulin glargine and insulin detemir can effectively reduce the dosage of insulin and reduce the risk of hypoglycemia.