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目的 观察非动脉炎性前部缺血性视神经病变(NAION)患者血浆内皮素- 1(ET -1) )浓度变化,探讨ET 1与NAION的关系。 方法 通过放射免疫法(RIA)测定41例NAION患者及年龄相匹配的15例非病变对照者血浆ET -1水平。将NAION患者按视盘水肿程度分为重度水肿组、轻度水肿组、水肿消退组3组;并根据病程分为发病14d内(病程1组)、15～3 0d(病程2组)、3 1～60d(病程3组)和61～180d(病程4组)等4组。对比分析不同性别、视盘水肿程度以及病程的NAION患者血浆ET- 1水平。 结果 NAION患者比对照者血浆ET 1水平增高(t =5 .0 2 ,P <0 .0 5 )。不同性别NAION患者血浆ET- 1水平无明显差异。视盘水肿程度不同组间血浆ET- 1水平差异有统计学意义(F =4.65 ,P <0 .0 5 ) ;血浆ET 1-水平随病程延长逐渐下降,不同病程组间血浆ET 1水平差异有统计学意义(F =4.2 9,P <0 .0 5 ) ;病程1、2、3组与对照组血浆ET 1水平比较,差异也有统计学意义(t1=5 .92 ,t2 =3 .47,t3 =2 .18,P1<0 .0 1,P2 <0 .0 5 ,P3 <0 .0 5 )。 结论 NAION患者血浆ET- 1水平可能与视盘损害程度和病程长短相关联。
Objective To observe the changes of plasma endothelin - 1 (ET - 1) levels in patients with noninfarmed anterior ischemic optic neuropathy (NAION) and to explore the relationship between ET 1 and NAION. Methods Plasma ET-1 levels were measured by radioimmunoassay (RIA) in 41 patients with NAION and 15 matched age-matched controls. The patients with NAION were divided into 3 groups: severe edema group, mild edema group and edema edema group according to the degree of optic disc edema.According to the course of disease, the patients were divided into 14 days after onset of disease (group 1), 15 to 30 days (group 2) ~ 60d (duration of 3 groups) and 61 ~ 180d (duration of 4 groups) and other 4 groups. The levels of plasma ET-1 in NAION patients with different gender, optic disc edema and course of disease were compared and analyzed. Results Compared with the control group, plasma ET 1 levels were significantly increased in NAION patients (t = 5.22, P <0.05). There was no significant difference in plasma ET-1 levels between different gender NAION patients. The level of plasma ET-1 in different groups of optic disc edema was significantly different (F = 4.65, P <0.05). The level of plasma ET-1 gradually decreased with the prolongation of course of disease. Statistical significance (F = 4.2 9, P <0.05). There was also a significant difference in plasma ET 1 levels between the two groups in the duration of treatment 1, 2 and 3 (t1 = 5.92, t2 = 3.47 , t3 = 2.18, P1 <0. 01, P2 <0. 05, P3 <0. 05). Conclusions Plasma ET-1 level in patients with NAION may be related to the extent of optic disc damage and duration of disease.