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目的探讨嗅神经母细胞瘤的临床病理学特点及诊断要点。方法对我院收治的1例嗅神经母细胞瘤患者的临床资料、病理形态学及免疫组化特点进行分析,并结合文献对其诊断及鉴别诊断进行探讨。结果本例镜下见肿瘤细胞大小一致,为小细胞,细胞质稀少,核膜和背景不清楚,呈明显的纤维状和网状。间质中有丰富的血管,肿瘤细胞被间质分隔成团。免疫组化染色显示:CK(+),EMA(+),Syn(+),NSE(+),LCA(-),CK5(-),CK7(-),NF(-)和Melan A(-)。结论嗅神经母细胞瘤非常罕见,提高对该病临床病理特点的认识,临床可减少误诊。
Objective To investigate the clinicopathological characteristics and diagnosis of olfactory neuroblastoma. Methods The clinical data, pathomorphology and immunohistochemical characteristics of one patient with olfactory neuroblastoma admitted to our hospital were analyzed. The diagnosis and differential diagnosis of the patients with olfactory neuroblastoma were analyzed. Results In this case, the size of tumor cells was uniform, small cells, sparse cytoplasm, unclear nuclear membrane and background, showing obvious fibrous and reticular. The stroma is rich in blood vessels, tumor cells are separated into groups by the stroma. Immunohistochemical staining showed that the expression of CK (+), EMA (+), Syn (+), NSE (+), LCA (-), CK5 (-), CK7 (-), NF (-) and Melan A ). Conclusion Olfactory neuroblastoma is very rare, which can improve the understanding of the clinicopathological features of the disease and reduce the misdiagnosis clinically.