The launderability of wool fabrics treated by nano fir shing agent influences directly the functional endurance of he treated wool fabric. In order to investigate the effect of wool fibers surface modification on the functional endurance of nano fmishinp wool fibers, in this paper, for the first time wool fibers were chemically modified by using NaCIO aqueous and KMnO4 aqueous, and then chemically modified wool fibers and native wool fibers were treated using nano ZnO finishing agent, respectively. The launderability of wool fibers treated by nano finishing agent was investigated. The experimental results show that the chemically modified wool fibers have a good launderaility after being treated by nano ZnO finishing agent treating. The surface morphologies of wool fibers were observed by using SEM. It is got that there is a strong adhesion between nano ZnO and wool surface through XPS analysis.