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用马利兰治疗三只贫血恒河猴,使其β类珠蛋白肽链合成述率(γ/γ+β)及搞碱血红蛋白(HbF)升高。珠蛋白肽链合成速率升高时间较HbF水平的升高提前10天左右。γ/γ+β升高幅度与马利兰的剂量及疗程长短有关。
Treatment of three anemic rhesus monkeys with melilide resulted in an increased β-globin peptide chain formation rate (γ / γ + β) and an increase in HbF. The rate of synthesis of globin peptide chain increases faster than that of HbF by about 10 days. The increase of γ / γ + β is related to the dose and course of treatment of Maryland.