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目的 :化疗后白细胞减少时先给高剂量Granocyte,待白细胞正常用量减半并设对照组观察效果。 方法 :5 0例消化道癌患者化疗后白细胞降至 <3 0× 10 9/L。A组 ,每日皮下注射Granocyte 10 0 μg ,共 10日。B组 ,每日皮下注射高剂量Granocyte 2 5 0 μg ,3～ 5日后 ,当白细胞升至 >4 0× 10 9/L ,剂量减半 ,再用 5～ 7日 ,总用药 10日。结果 :观察 5 0例 ,男性 37例 ,女性 13例。计食管癌 9例 ,胃癌 35例 ,肠癌 6例。A组 37例 ,B组 13例 ,共 5 0例 ,总有效率 96 0 % (显效 73 0 % ,有效 2 1 6 % )。B组 10 0 0 % (显效 6 9 2 % ,有效 30 8% ) ,全组 3例 (6 % )有发热副反应。结论 :使用高低剂量Granocyte升白疗效好 ,效果稳定。
Objective: Chemotherapy after leukopenia give high doses of Granocyte to be half the normal dosage of leukocytes and set the control group to observe the effect. Methods: Fifty cases of patients with digestive tract cancer were treated with chemotherapy to reduce the number of white blood cells to <30 × 10 9 / L. Group A, daily subcutaneous injection of Granocyte 10 0, a total of 10 days. Group B, the daily high-dose subcutaneous injection of Granocyte 250μg, 3 to 5 days, when the white blood cells rose to> 40 × 10 9 / L, the dose halved, then 5 to 7 days, the total medication on the 10th. Results: 50 cases were observed, 37 males and 13 females. 9 cases of esophageal cancer, 35 cases of gastric cancer, 6 cases of intestinal cancer. A group of 37 cases, B group of 13 cases, a total of 50 cases, the total efficiency of 96 0% (effective 73 0%, effective 21 6%). Group B, 100% (effective 6 9 2%, effective 30 8%), 3 patients (6%) had fever side effects. Conclusion: The use of high and low dose of white granulocyte efficacy is good, the effect is stable.