随着肿瘤免疫研究的发展,近年来国内外广泛应用甲胎蛋白(AFP)作为原发性肝癌的普查和临床诊断,对肝癌的早期诊断作出了很大的贡献。但不是所有原发性肝癌血清甲胎蛋白均呈阳性,有些病例临床上符合原发性肝癌,甚至手术切除或尸解病理确诊是肝癌,但血清甲胎蛋白检验始终是阴性,这就是所谓假阴性的问题。综合国内外的文献资料大约占13～ With the development of tumor immunology research, AFP has been widely used both at home and abroad as a general survey and clinical diagnosis of primary liver cancer, and has made great contributions to the early diagnosis of liver cancer. But not all primary liver cancer serum alpha-fetoprotein is positive, some cases are clinically consistent with primary liver cancer, and even surgical resection or autopsy pathology is confirmed by liver cancer, but serum alpha-fetoprotein test is always negative, this is the so-called false Negative question. The total domestic and foreign literature accounts for about 13~