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目的观察银杏达莫注射液对老年慢性肾功能不全患者造影剂肾病(CIN)的影响。方法接受冠状动脉造影的老年慢性肾功能不全患者63例,随机分为观察组(32例)及对照组(31例)。两组均在造影前常规水化治疗。观察组在水化基础上,术前6h予银杏达莫注射液25ml加入生理盐水250ml静脉滴注,术后第1和第2天重复使用1次。观察两组造影前后血清肌酐(SCr)及肌酐清除率(Ccr)水平,比较CIN发病率。结果两组术后48hSCr均较术前升高,Ccr较术前降低(P<0.05)。术后48h,观察组SCr低于对照组[(191.0±22.3)μmol/L vs.(199.5±26.6)μmol/L](P<0.05),观察组Ccr高于对照组[(36.1±4.2)ml/min vs.(33.4±6.3)ml/min](P<0.05);观察组术后CIN发病率低于对照组(9.4%vs.12.9%)(P<0.05)。结论银杏达莫注射液对肾功能有保护作用,能减少老年慢性肾功能不全患者冠状动脉介入治疗术后CIN的发病率。
Objective To observe the effect of Yinxingdamo injection on contrast-induced nephropathy (CIN) in elderly patients with chronic renal insufficiency. Methods 63 elderly patients with chronic renal insufficiency undergoing coronary angiography were randomly divided into observation group (32 cases) and control group (31 cases). Both groups were routine hydration before contrast. Observation group on the basis of hydration, preoperative 6h to ginkgo Damo injection 25ml saline 250ml intravenous infusion, 1 and 2 days after the repeated use of 1. The levels of serum creatinine (SCr) and creatinine clearance (Ccr) before and after angiography were compared between the two groups to compare the incidence of CIN. Results The postoperative 48h SCr of both groups was higher than that before operation, and the Ccr was lower than that before operation (P <0.05). The level of SCr in the observation group was significantly lower than that in the control group [(191.0 ± 22.3) μmol / L vs. (199.5 ± 26.6) μmol / L, P < ml / min vs. 33.4 ± 6.3 ml / min] (P <0.05). The incidence of postoperative CIN in the observation group was lower than that in the control group (9.4% vs. 12.9%, P <0.05). Conclusion Ginkgo biloba injection has a protective effect on renal function and can reduce the incidence of CIN after coronary intervention in elderly patients with chronic renal failure.