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目的了解血管紧张素转化酶（ＡＣＥ）基因多态性与原发性局灶节段性肾小球硬化（ＦＳＧＳ）的关系。方法聚合酶链反应测定３１例ＦＳＧＳ患者及１１６例健康人群的ＡＣＥ基因多态性。结果ＦＳＧＳ患者与一般人群对照组之间ＡＣＥ基因型频率差异不明显；ＦＳＧＳ肾功能不全组、ＦＳＧＳ肾功能正常组及一般人群对照组之间ＤＤ型频率差异有显著性。结论ＡＣＥ基因的多态性对中国人ＦＳＧＳ发病无明显的影响；ＤＤ型基因是ＦＳＧＳ发生肾功能不全的易感因素。
Objective To investigate the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and primary focal segmental glomerulosclerosis (FSGS). Methods Polymerase chain reaction was used to detect ACE gene polymorphism in 31 FSGS patients and 116 healthy controls. Results There was no significant difference in the frequency of ACE genotypes between FSGS patients and control subjects. There was significant difference in the frequencies of DD genotype among FSGS renal insufficiency patients, FSGS renal dysfunction patients and control subjects. Conclusion The polymorphism of ACE gene has no significant effect on the incidence of FSGS in Chinese. DD gene is a susceptible factor of renal failure in FSGS.