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目的 评价衰减校正 (AC)在1 8F 脱氧葡萄糖 (FDG)SPECT显像中的临床价值。方法 对病理检查证实的 36例恶性肿瘤和 4例良性肿物患者进行1 8F FDGSPECT显像 ,进行迭代法重建AC和非衰减校正 (NAC) ,并计算两者的肿瘤与本底比值 (T B)。 2 8例正常人进行了胸部1 8F FDGSPECT显像。将左室心肌分为 9个节段 ,用 5分法 (0 :正常 ;1分 :轻度减少 ;2分 :中度减少 ;3分 :明显减少 ;4分 :缺损 )对AC与NAC图像的各心肌节段进行评分。结果 36例恶性肿瘤患者中 34例AC与NAC均诊断为恶性 ,两者均检出 5 5个病灶 ,2例 (6 % )AC与NAC均为假阴性 ,4例良性病变AC与NAC均为阴性。肺部肿瘤T B在AC后增加 (P <0 0 1) ,肺外肿瘤T BAC后降低 (P <0 .0 5 ) ,不同部位肿瘤T B在AC与NAC间呈显著正相关 (P <0 0 1)。AC对病变的解剖位置、周围组织受累情况及深部病变显示更加清晰。全部 2 8例心肌显像者的左室前、后间壁 ,下、后壁在NAC影像均出现明显放射性衰减伪影 ,AC后显著改善 (P <0 0 1) ;17例 (6 0 .7% )心尖、6例 (2 1.4% )前壁心尖段放射性分布在AC后有轻度减低 (P <0 .0 1) ;AC后平均左室总分由NAC时的 10 .82± 2 .14下降为 3.6 4± 2 .2 3(P <0 0 1)。结论 AC虽未能增加肿瘤检出率 ,但可更清晰地显示肿瘤的位置?
Objective To evaluate the clinical value of attenuation correction (ACF) in 1 8F deoxyglucose (FDG) SPECT imaging. Methods 18F FDGSPECT imaging was performed on 36 malignant tumors and 4 benign masses confirmed by pathology. The AC and non-attenuation calibration (NAC) were reconstructed by iterative method. The ratio of tumor to background (TB) . Twenty-eight normal subjects underwent 18F FDGSPECT imaging of the chest. The left ventricular myocardium was divided into 9 segments and the AC and NAC images were scored using a 5-point method (0: normal; 1: mild decrease; 2: moderate reduction; 3: significantly reduced; Of the myocardial segments were scored. Results 34 cases of malignant tumors were diagnosed as malignant by AC and NAC, 55 cases were detected in both of them. AC and NAC were false negative in 2 cases (6%), AC and NAC in 4 cases were negative. The TB of pulmonary tumors increased after AC (P <0.01), and decreased after T BAC of extrapulmonary (P <0.05). There was a significant positive correlation between the TB of AC and NAC (P <0 0) 1). AC lesions on the anatomical location, the surrounding tissue involvement and deep lesions showed more clearly. Significant radioactive decay artifacts were observed in the anterior and posterior wall, posterior wall, inferior wall and posterior wall of all 28 myocardial imaging patients, and significantly improved after AC (P <0.01); 17 (60.7) %) Apical, 6 cases (2.14%) anterior parietal segment radioactivity distribution was slightly reduced after AC (P <0.01); AC after a mean total left ventricular NAC by 10 .82 ± 2. 14 decreased to 3.6 4 ± 2 .2 3 (P <0 0 1). Conclusion Although AC can not increase the detection rate of tumor, but can more clearly show the location of the tumor?